Listerine Mouthwash is 4.6x More Effective than Floss

Listerine Mouthwash is 4.6x More Effective than Floss

for Sustained Plaque Reduction Above the Gumline*

*Flossing by a hygienist
*Sustained plaque reduction above the gumline with continual twice-daily use. Plaque is graded 8 to 18 hours after product use.

A 12-week study reveals exciting data on the benefits of Listerine Antiseptic

Clinical 1: Efficacy of Supervised Mouth Rinsing and Flossing on Plaque and Gingivitis1


To evaluate the efficacy of twice-daily rinsing with Listerine® Antiseptic and brushing vs. flossing and brushing under once-daily supervision for the prevention and reduction of plaque and gingivitis.


  • Single center, randomized, supervised, examiner blind, controlled clinical trial conducted at ADA-Qualified site.
  • Following a complete prophylaxis, subjects were examined for oral soft tissue status, plaque, gingivitis, and gingival bleeding at Baseline, 4 weeks, and 12 weeks.
  • If assigned to a flossing group, subjects were given flossing instructions and demonstrated competency.
  • Product use was supervised once daily in person on weekdays with second daily and weekend product use unsupervised.



  • 156 subjects (18 years of age and older) with mild-to-severe gingivitis and no severe periodontitis, with no entry criteria on Modified Gingival Index (MGI)/plaque, but must have minimum of 10 gingival bleeding sites.
  • The efficacy outcomes included interproximal and whole-mouth mean modified Turesky Plaque Index (TPI), mean MGI, gingival bleeding, bleeding on probing depth, and probing depth.


This study also demonstrated that adding Listerine® Antiseptic Cool Mint to twice-daily brushing provided statistically significant reductions in gingivitis, gingival bleeding and bleeding on probing depth and probing depth compared to brushing and using a negative control rinse.



1. Mean Turesky Plaque Index (TPI)* P<0.001; comparing each investigational product vs. Control. Clinical 1 control = Brush + 5% Hydroalcohol Mouth Rinse.


Reference: Milleman, J., Bosma, M. L., McGuire, J. A., Sunkara, A., McAdoo, K., DelSasso, A., Wills, K., & Milleman, K. (2022). Comparative Effectiveness of Toothbrushing, Flossing and Mouthrinse Regimens on Plaque and Gingivitis: A 12-week virtually supervised clinical trial. Journal of Dental Hygiene : JDH, 96(3), 21–34.

For Dental Healthcare Professionals Only. For Educational Purposes Only.